Meptin Inhalation Solution Special Precautions

Patients with hyperthyroidism (the disease may be exacerbated); hypertension (blood pressure may be further increased); heart disease (palpitation, arrhythmia, exacerbation of heart disease and other symptoms may occur); diabetes mellitus (the disease may be exacerbated).
Important Precautions: Continuous use of excessive amounts of Meptin Inhalation Solution may cause cardiac arrhythmia and cardiac arrest. Special care should be taken in order not to exceed the recommended dose; in case of an asthma episode.
If the desired therapeutic effect is not achieved at recommended levels, Meptin Inhalation Solution should be discontinued. Special care should be discontinued. When Meptin Inhalation Solution is administered to children, they should be properly instructed on the method of use of this drug and adequately observed for any effects.
Patients and their families should be instructed to consult a physician for emergency treatment, and reassessment of therapy when the recommended dosing schedule is not effective in relieving severe episodes of asthma.
Effects on Laboratory Tests: Meptin Inhalation Solution tends to inhibit skin reactions in allergen tests. The drug should be withdrawn 12 hrs prior to such tests.
Other Precautions: Tissue damage in cardiac muscle was noted in oral toxicity study of procaterol HCl using rats and dogs, similar to other β₂-adrenergic agonists.
Dietary administration of procaterol HCl for 104 weeks was reported to cause mesovarian leiomyoma in SD rats. However, this tumor is rat species-specific and tends to develop during long-term administration of β₂-adrenergic agonists.
Use in pregnancy & lactation: Meptin Inhalation Solution should be administered to pregnant or possibly pregnant women only if the expected therapeutic benefit is thought to outweigh any possible risk. The safety of Meptin Inhalation solution during pregnancy has not been established.
Nursing should be interrupted before starting treatment with Meptin Inhalation Solution. Rat studies showed that procaterol HCl is excreted in breast milk.
Use in children: The safety of Meptin Inhalation Solution in low birth weight infants, neonated and suckling infants has not been established.
Use in the elderly: Dosage adjustment or other appropriate measures should be considered when prescribing Meptin Inhalation Solution to elderly patients because they may be physiologically more sensitive to the drug than younger patients.